Adhesion of Porphyromonas gingivalis to Human Gingival Fibroblasts and Collagen.
نویسندگان
چکیده
منابع مشابه
Cytotoxicity of Porphyromonas gingivalis toward cultured human gingival fibroblasts.
Direct cytotoxicity of black-pigmented anaerobic rods was studied on the confluent monolayer of human gingival fibroblasts in vitro. Only strains of Porphyromonas gingivalis caused morphological alteration (cell-rounding) and notable depression of viability of fibroblasts. To determine the location of the cytotoxicity, bacterial surface components, i.e., outer membrane, lipopolysaccharide, fimb...
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We suggest here that Porphyromonas gingivalis DNA may function as a virulence factor in periodontal disease through expression of inflammatory cytokine. The bacterial DNA markedly stimulated in a dose-dependent manner interleukin-6 (IL-6) production by human gingival fibroblasts. The stimulatory action was eliminated by treatment with DNase but not RNase. The stimulatory effect was not observed...
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Recognition of pathogen-associated molecular patterns that activate IL-1β is regulated by inflammasomes, predominantly of the nucleotide-binding oligomerization domain-like receptor (NLR) family. NLRP3 inflammasome is involved in the innate immune responses in periodontal disease. This is an inflammatory condition that destroys the tooth-supporting (periodontal) tissues, initiated by the subgin...
متن کاملAdhesion and Proliferation of Human Gingival Fibroblasts on Root Surfaces following Photodynamic Therapy: An In Vitro Study
Background and Aim: Previous studies have shown that some dyes used in photodynamic therapy (PDT) have a low pH and may cause root demineralization and remove the smear layer. This study aimed to assess and compare the effects of root biomodification with citric acid and PDT on the adhesion and proliferation of human gingival fibroblasts (HGFs). Materials and Methods: In this in vitro experime...
متن کاملHeterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts
Periodontal (gum) disease is a highly prevalent infection and inflammation accounting for the majority of tooth loss in adult population worldwide. Porphyromonas gingivalis is a keystone periodontal pathogen and its lipopolysaccharide (PgLPS) acts as a major virulence attribute to the disease. Herein, we deciphered the overall host response of human gingival fibroblasts (HGFs) to two featured i...
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ژورنال
عنوان ژورنال: JOURNAL OF DENTAL HEALTH
سال: 1992
ISSN: 0023-2831
DOI: 10.5834/jdh.42.23